Despite many studies in the gas phase, O(3P) has been studied only infrequently in solution, mostly due to the shortcomings of the methods used to generate it. In the past decade, renewed interest in utilizing O(3P) as an oxidant and as a model system for cytochrome P450 oxidations has spurred new development and study of precursors which photochemically release O(3P) in the condensed phase. The known chemistry of O(3P) strongly suggests that it could be applied to current footprinting techniques without the associated drawbacks of the most commonly used reagent hydroxyl radical. This research seeks to develop biologically compatible, photoactivatable O(3P) precursors.